The Glendale Woman's Club began in 1901 as the "Self Culture Club of Glendale." A year later they joined the Arizona Federation of Women's Clubs, as the sixth club to join this Federation in Arizona. The club incorporated as the Glendale Woman's Club in 1914.

Through hard work, club members raised the fund to build a clubhouse in 1912 at a cost of $2,947. In the Craftsman Bungalow style, the building has been used over the decades for many functions, including meetings, weddings, youth activities, and other gatherings. The building also housed the local library for a few years during World War I. Later, when the library moved to a city building, the women's club members continued to volunteer there. Women's Club members also worked to raise money for the first drinking fountain in the city park; for food to benefit veterans; and for organizations such as the Camp Fire Girls. The Glendale Woman's Club Building has become a community landmark because it was used for so many functions. It is on the National Register of Historic Places.